However, the pier historic importance runs far deeper

Two reviewers (YKL and SS) independently scanned all titles and abstracts that indicated the study was a randomised controlled trial evaluating the use of tiotropium mist inhaler among patients with chronic obstructive pulmonary disease. After obtaining full reports of potentially relevant trials, the same reviewers independently assessed eligibility from full text articles. Studies were selected for inclusion if they were parallel group randomised controlled trials of tiotropium mist inhaler compared with placebo for the treatment of chronic obstructive pulmonary disease, if treatment duration was for at least 30 days, and if they provided numerical data on mortality.Study characteristics and quality and risk of bias assessmentWe used a prespecified protocol to record the location and duration of the randomised controlled trials (in years), the dose and frequency of tiotropium mist inhaler and placebo, mean age and sex of participants, mean forced expiratory volume in one second (FEV1), and smoking status.The Cochrane toolkit was used for the assessment of bias in evaluating each trial for the reporting of randomisation, allocation concealment, the use of blinding of participants and staff, and information on loss to follow up or withdrawal rates.21 In accordance with the Cochrane handbook of systematic reviews, we assessed the quality of data on adverse effects by recording how they were monitored and recorded by the investigators.21Outcome measuresThe primary outcome measure was prespecified as mortality from any cause.

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pandora charms A famed pier where 123 passenger boarded the ill fated Titanic has been saved from collapsing into the sea, and plans are being drawn up to fully restore it as an interactive viewing platform.Known locally as Heartbreak Pier, the iconic landmark was the last point of land contact for passengers who boarded Titanic, from the port then known as Queenstown. However, the pier historic importance runs far deeper. Originally constructed in the mid 19th century pandora charms, it has been estimated that in excess of one million people used the pier as their departure point to emigration ships.It is believed the pier will be 150 years old next year.Receive our lunchtime briefing straight to your inboxBorder duty allowance for 710 soldiers ‘absolute madness’, says Alan KellyA 10 year old boy got photobombed by a shark and it’s pretty terrifyingFine Gael email instructs TDs and Senators to play down Enda Kenny’s gaffe on SF coalitionPlans revealed for 300th anniversary of one of Cork’s oldest churches30 surreal hours in LimerickPaddy brings the country pub to the heart of Limerick cityDisingenuous Dylan Hartley a dangerous disgraceA sporting essay: Eimear Ryan on the fear of winning and much morePetrol station that sold 88m EuroMillions ticket runs out of celebratory cut price fuelThat awkward moment when the White House can’t spell Theresa May’s nameNEWSAll New Renault Mgane Launches in Ireland Pricing from 155 per monthAll New Renault Mgane Launches in Ireland Pricing from 155 per monthWORLDLouise Galvin: Why Women’s Sevens is now in vogueBUSINESSGlanbia and Tesco put focus on big food dealsCircle Oil assets sold offSPORTIt’s win or bust for First Division clubsFaugheen in good form for long awaited comebackLIFESTYLETrend of the week: Shirt and jeans, the perfect coupleBack to the future how 60s changes in design still influences furniture today pandora charms.

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